1986 Jul;90(1):45-51. doi: 10.1378/chest.90.1.45. Cats suffering from asthma will have their condition improved in more than one way. Theophylline was first used for asthma therapy in the 1930’s, and provides relief today for many asthma patients without the side effects of the traditional medications. Theophylline, despite its adverse effects and narrow therapeutic range, as discussed above, is still a potent bronchodilator. Clinical pharmacokinetics of beta-agonists. Toxic (unwanted) side effects. This action appears to be due to enhancement of calcium uptake through an … Dronabinol: (Major) Use caution if coadministration of dronabinol with theophylline, aminophylline is necessary, and monitor for increased theophylline levels and theophylline-related adverse effects. Adverse effects of administration of theophylline were reported in 298 patients (10.8 percent). This is of practical importance, since 1.3% of pregnant women have asthma. Pregnancy. sweating. Theophylline crosses the placenta, resulting in potentially dangerous serum theophylline concentrations in the neonate (SEDA-5, 3). Chest. Adverse CNS effects, which are often more severe in children than in adults, include headache, irritability, restlessness, nervousness, insomnia, dizziness, reflex hyperexcitability, and seizures. Commonly reported side effects of theophylline include: acid-base imbalance. A 48-year-old member asked: Adverse effects of interferon? Raise the heart rate 4. Theophylline is metabolized primarily by the liver, and commonly interacts with other medications. 2001;24(14):1065-80. doi: 10.2165/00002018-200124140-00005. unusual tiredness or weakness. Theophylline Adverse Effects. Along with its needed effects, theophylline may cause some unwanted effects. Side effects of theophylline at peak serum concentration less than 20 mcg/mL include: Central nervous system excitement, headache , insomnia , irritability, restlessness, seizure Diarrhea , nausea , vomiting Careful product selection, the slow progressive titration of dose over nine days, and the accurate measurement and interpretation of serum theophylline concentration can prevent adverse effects and interactions. Combined beta agonists and methylxanthines in asthma. Most commonly, the side effects of Theophylline include central nervous system excitement, vomiting, fever, … Incidence not known Blurred vision chest pain or discomfort cough dizziness fainting fast, slow, or irregular heartbeat headache increase in urine volume infection at … Some side effects may occur that usually do not need medical attention. Many different. 0. Serious side effects of Elixophyllin include seizures and heart arrhythmias. Because of problems with side effects, there have been attempts to improve on theophylline, and recently there has been increasing interest in selective phosphodiesterase (PDE) inhibitors, which have the possibility of improving the beneficial and reducing the adverse effects of theophylline. Some of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE III (e.g., hypotension, tachycardia, headache, and emesis) and adenosine receptor antagonism (e.g., alterations in cerebral blood flow). B. Braun Medical, Irvine, CA. Caffeine increases CNS and cardiac adverse effects; can also increase theophylline levels. Asthma deaths and theophylline/beta2-agonist therapy. Plasma-theophylline concentration is measured 5 days after starting oral treatment and at least 3 days after any dose adjustment. Theophylline Er Side Effects Nausea/vomiting, stomach/abdominal pain, headache, trouble sleeping, diarrhea, irritability, restlessness, nervousness, shaking, or increased urination may occur. Theophylline increases the force of contraction of diaphragmatic muscles. headaches. Insomnia 3. Cardiac arrhythmias during the combined use of beta-adrenergic agonist drugs and theophylline. Theophylline has a very narrow therapeutic window, and its interaction with various other drugs has led to the limitation of its use. Charles B. Cairns, in Clinical Asthma, 2008. Participants will be specifically asked about respiratory tract infections in the previous 12 weeks and whether bone fractures have occurred. Drugs Aging. If any of these effects last or get worse, tell your doctor or pharmacist promptly. NIH Other side effects include sleeplessness, increased drinking, eating, and urinating. Increase blood flow in the kidneys 6. Although theophylline has side effects when used in bronchodilator doses, increasing evidence shows that it has significant antiinflammatory effects in chronic obstructive pulmonary disease at lower plasma concentrations. Some side effects may not be reported. These signs include seizures and … Theophylline (theophylline)." Theophylline-terbutaline, a steady state study on possible pharmacokinetic interactions with special reference to chronopharmacokinetic aspects. Like all medicines, theophylline can cause side effects for some people. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The adverse effects of theophylline include: Gastrointestinal disorders such as nausea, vomiting, gastro-oesophageal reflux. These side effects often improve and disappear completely after you have been using beta-2 agonists for a few days or weeks. It can also be given intravenously (into a vein) for treatment for severe asthma attacks or COPD exacerbations. Adverse effects related to theophylline use are related directly to serum level of the drug. However, long-term therapy with theophylline should probably be avoided when other alternatives are available in patients with cor pulmonale, liver dysfunction, cardiac decompensation, … Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Mild toxicity = GI distress and restlessness; More severe toxicity = dysrhythmias and seizures . Excessive hunger and/or thirst 6. You may report side effects to Health Canada at 1-866-234-2345. Theophylline may cause these conditions to get worse. Last updated on Sep 2, 2020. Side Effects to Report. Drug Saf. However, theophylline is a CNS stimulant, and it lowers arterial blood pressure, increases diuresis, displays cardiotonic activity, and has a specific effect on the gastrointestinal tract. Vomiting 4. USA.gov. Find patient medical information for theophylline oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. However, there is interest in exploring its antiinflammatory effects and its potential to reverse corticosteroid resistance at lower doses that would largely avoid side effects. Br J Clin Pharmacol. Gastrointestinal disturbances, reported in 7.8 percent of the recipients, were the most common adverse effects. Such preparations, often with a mild sedative added, dominated the market for oral theophylline products until 1975 when the addition of ephedrine was demonstrated to add adverse effects without additive clinical benefit . Lactation: Theophylline is excreted into breast milk and may cause irritability or other signs of mild toxicity in nursing human infants; serious adverse effects in … Theophylline is appropriate for use on cats and dogs when it is administered under the guidance of a veterinarian. The adverse effects of theophylline include nausea (most common), vomiting, tremor, headache, central nervous system stimulation, insomnia, palpitations, arrhythmias, and convulsion (rare). View Coupon Prices. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to theophylline: compounding powder, intravenous solution, oral capsule, oral capsule extended release, oral elixir, oral solution, oral syrup, oral tablet, oral tablet extended release. These drugs, including "beta 2-specific" agonists, also have the potential to produce adverse cardiovascular effects when used clinically. Adverse effects can occur within the range 10–20 mg/litre and both the frequency and severity increase at concentrations above 20 mg/litre. Theophylline systemic 200 mg (WARRICK 1660), We comply with the HONcode standard for trustworthy health information -, confusion about identity, place, and time, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, pounding, or irregular heartbeat or pulse, pain or discomfort in the arms, jaw, back, or neck, shakiness in the legs, arms, hands, or feet, vomiting of blood or material that looks like coffee grounds. Oral administration of theophylline is effective but has resulted in side effects when dosages are increased to the therapeutic levels required for improving sense of … Adverse effects can occur with plasma theophylline concentrations of 10 mg/L to 20 mg/L. Reporting side effects . There are a number of theophylline side effects that you should report immediately to your healthcare provider. Clin Pharmacokinet. Theophylline is a prescription medication that’s used to treat asthmatic bronchitis, chronic obstructive pulmonary disease and congestive heart failure in dogs.It is a bronchodilator used to reduce inflammation and swelling of muscles in the lungs and chest. Elixophyllin (theophylline) is a bronchodilator used to relieve and prevent airway narrowing (bronchospasm) in patients with asthma. Applies to theophylline: oral capsule extended release 24 hr, oral elixir, oral solution, oral tablet extended release, oral tablet extended release 12 hr, oral tablet extended release 24 hr. -Seizures in elderly patients with serum theophylline under 20 mcg/mL may be due to decreased protein binding causing higher unbound (pharmacologically active) theophylline levels. Beta-adrenergic agonists, when administered alone or concomitantly with methylxanthines are capable of producing lesions of myocardial necrosis and an increased incidence of cardiac arrhythmias in several species of animals. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2008;25(5):415-43. doi: 10.2165/00002512-200825050-00005. suddenly noticeable heartbeats (palpitations) muscle cramps. Adverse reactions associated with Theophylline are generally mild when peak serum Theophylline concentrations are <20 mcg/mL and mainly consist of transient caffeine-like adverse effects such as nausea, vomiting, headache, and insomnia. Relax bronchial smooth muscle 2. It facilitates respiration by widening bronchial tubes and relaxing muscles. Theophylline works by relaxing the smooth muscles of the airways while relieving inflammation and a… Potential adverse effects of bronchodilators in the treatment of airways obstruction in older people: recommendations for prescribing. Interestingly in children with a severe asthma exacerbation, the addition of IV aminophylline to beta-agonists and corticosteroids im- proves lung function within 6 hours of treatment. Use of theophylline is limited by its adverse effects, which range from commonly occurring gastrointestinal symptoms to palpitations, arrhythmias and reports of myocardial infarction. Data sources include IBM Watson Micromedex (updated 2 Feb 2021), Cerner Multum™ (updated 3 Feb 2021), ASHP (updated 29 Jan 2021) and others. See a GP if your side effects persist, as your dose may need to be adjusted. -Consider the possibility of non-convulsive status epilepticus in patients with abnormal central nervous system function and theophylline use. Theophylline is an oral medication used to treat asthma and other lung diseases. Increase the contractility and efficiency of the myocardium 3. Asthma medications and their potential adverse effects in the elderly: recommendations for prescribing. Adverse reactions associated with theophylline are generally mild when peak serum theophylline concentrations are < 20 mcg/ mL and mainly consist of transient caffeine-like adverse effects such as nausea, vomiting, headache, and insomnia. PMID: Anxiety 2. Learn who it’s for, how it works, its side effects, warnings, and more. Adverse effects of theophylline-beta agonist interactions. Jonkman JH, Borgström L, van der Boon WJ, de Noord OE. Common side effects of Elixophyllin include nausea, vomiting, diarrhea, headaches, irritability, flushing, and palpitations. You may report them to the FDA. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Stimulate central nervous system, especially the medullaryrespiratory center By relaxing the smooth muscles of the airways, Theophylline widens the bronchi and permits your cat to increase the oxygen int… -A few seizures have been reported in patients with underlying neurological disease or in elderly patients with serum theophylline under 20 mcg/mL. Increased urination Symptoms of nervous system excitement (such as anxiety and insomnia) and stomach upset tend to pass with repeated use and adjustment of the dosage. vomiting of blood or material that looks like coffee grounds. -Seizures in patients with serum theophylline under 20 mcg/mL were generally milder (than those from overdose) such as being transient, not requiring anticonvulsants, and no neurological residuals. The Yellow Card Scheme allows you to report side effects of any medicine you're taking. 7. Careful product selection, the slow progressive titration of dose over nine days, and the accurate measurement and interpretation of serum theophylline concentration prevent adverse effects and interactions. If necessary, the infusion could be temporarily stopped for 12-24 hours until theophylline adverse effects subsided. Psychiatric disorders such as anxiety. However, the patient can still experience side effects with this drug. In Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions (Fifteenth Edition), 2006. In people with liver problems, it can sometimes lead to a dangerous build-up of medication in the body. BACKGROUND: Although theophylline is recommended by current guidelines for the management of asthma in patients with persistent symptoms, theophylline has a narrow therapeutic index, requiring individual dose titration and regular monitoring of serum theophylline concentrations to avoid adverse effects. What side effects can this medication cause? Check with your doctor immediately if any of the following side effects occur while taking theophylline: Get emergency help immediately if any of the following symptoms of overdose occur while taking theophylline: Some side effects of theophylline may occur that usually do not need medical attention. None of the drugs given alone was associated with significant adverse effects but both ephedrine-theophylline combinations (with and without hydroxyzine) were associated with insomnia, nervousness, and gastrointestinal complaints. Adverse effects The use of theophylline is complicated by its interaction with various drugs and by the fact that it has a narrow therapeutic window. However, during the 2nd week the score for headaches decreased to the same level as in the theophylline treatment group. These side effects may go away during treatment as your body adjusts to the medicine. As a result, the extent to which the concomitant administration of these drugs may contribute to adverse clinical effects needs further clarification. This medicine is used to treat the symptoms of asthma, bronchitis, and emphysema. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. How to take theophylline. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Corticosteroid and theophylline related adverse effects [ Time Frame: 50 weeks ] Adverse effects measured include convulsions, stomach discomfort, headache, insomnia, palpitations, weight gain, bruising. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Theophylline Er Side Effects Nausea/vomiting, stomach/abdominal pain, headache, trouble sleeping, diarrhea, irritability, restlessness, nervousness, shaking, or increased urination may occur. However, there is interest in exploring its antiinflammatory effects and its potential to reverse corticosteroid resistance at lower doses that would largely avoid side effects. The main side effects of theophylline include: nausea and vomiting ; diarrhoea ; palpitations ; a rapid heartbeat (tachycardia) an irregular heartbeat ; headaches ; problems sleeping ; See a GP if you have any of these side effects, as your dose may need to be reviewed. IL-10 Release IL-10 has a broad spectrum of antiinflammatory effects, and there is evidence that its secretion is reduced in COPD (25). It helps open up the airways in your lungs to make it easier to breathe. Its use must be monitored by direct measurement of serum theophylline levels to avoid toxicity. 5 Recently there has been interest in using theophylline at a low dose in COPD to achieve plasma levels of 1 to 5 mg/L. Make sure to limit your intake of caffeine because theophylline causes similar side effects like headache, feeling jittery, or trouble sleeping. Deriphyllin is the brand name for the combination of two very similar generic drugs: etophylline and theophylline 1 2 3. Many patients experience minor adverse effects of theophylline therapy, and for this reason the drug is usually only prescribed for the prevention of asthma attacks, after other anti-asthma drugs have failed. Theophylline is a relatively poor bronchodilator, as adverse effects limit the dose and make it less effective than inhaled bronchodilators. Reduction of theophylline dosage usually reduces the incidence and severity of adverse gastric and CNS effects; however, if these adverse effects persist, the drug may have to be withdrawn. 1990 Apr;18(4):270-94. doi: 10.2165/00003088-199018040-00002. This site needs JavaScript to work properly.  |  However, a plasma concentration in this range is required in most people to achieve a satisfactory clinical effect. N Engl J Med. Medically reviewed by Drugs.com. It is typically taken by mouth for the long-term control and maintenance of asthma, COPD (including emphysema and chronic bronchitis), and other chronic lung diseases. Not much is yet known about the adverse effects of this medicine, but the following effects are possible: 1. Some … Severe toxic effects can occur but are rare. Therefore an interaction should be considered if any unexplained reduction in theophylline efficacy or an increase in theophylline-related adverse effects (e.g., headache, nausea or tremor) occur, and theophylline concentrations should be monitored accordingly. Other medicines can also cause abnormal build-up of theophylline in the body and this should always be checked by your doctor. NLM Given the low cost of theophylline, and its similar efficacy and rate of side effects compared with other drugs, we suggest that theophylline, when given with bronchodilators with or without steroids, is a cost-effective and safe choice for acute asthma exacerbations. THEOPHYLLINE is a bronchodilator. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Nicklas RA, Balazs T. Beta-adrenergic agonists, when administered alone or concomitantly with methylxanthines are capable of producing lesions of myocardial necrosis and an increased incidence of cardiac arrhythmias in several species of animals. In addition, beta agonists and methylxanthines can interact to potentiate or lessen effectiveness and theoretically increase the risk to the patient. Coleman JJ, Vollmer WM, Barker AF, Schultz GE, Buist AS. Diarrhea 5. Adenosine antagonism is likely to account for some of the serious side effects of theophylline, such as seizures and cardiac arrhythmias through blockade of A 1 receptors. Theophylline is well absorbed when taken orally as a rapid-release tablet or when administered as a liquid solution. Available for Android and iOS devices. Enprofylline produced more headaches during the 1st week than theophylline did. 1. 1 doctor agrees. Adverse Effects. Theophylline is used in the treatment of reversible airway obstruction due to chronic asthma, chronic bronchitis, or COPD. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Intravenous Aminophylline. More serious effects are haematemesis, convulsions, and supraventricular and ventricular … In fact, a medical history book recorded that people started to drink tea to prevent respiratory diseases several hundreds years ago. HHS Dr. Herbert Duvivier answered. [Ref], Very common (10% or more): Vomiting (93% in acute overdose, 61% with chronic overdose), abdominal pain (21% in acute overdose, 12% with chronic overdose), diarrhea (14% with chronic overdose), Common (1% to 10%): Hematemesis (2% with chronic overdose), Frequency not reported: Nausea, vomiting, persistent vomiting (at serum concentrations over 20 mcg/mL), diarrhea[Ref], Very common (10% or more): Tremors (38% in acute overdose, 16% with chronic overdose), seizures (14% in acute overdose, 14% with chronic overdose), Frequency not reported: Headache, intractable seizures (at serum concentrations over 20 mcg/mL), seizures[Ref], Very common (10% or more): Hyperglycemia (98% in acute overdose, 18% with chronic overdose), hypokalemia (85% in acute overdose, 44% with chronic overdose), acid/base disturbance (34% in acute overdose, 9% with chronic overdose), Frequency not reported: Hypercalcemia (in a hyperthyroid patient), hypervolemia[Ref], Very common (10% or more): Nervousness (64% in acute overdose, 21% with chronic overdose), disorientation (7% in acute overdose, 12% with chronic overdose), Frequency not reported: Insomnia, irritability, restlessness[Ref], Uncommon (0.1% to 1%): Rhabdomyolysis (7% in acute overdose), Frequency not reported: Fine skeletal muscle tremors[Ref], Very common (10% or more): Death (21% in acute overdose, 10% with chronic overdose), Frequency not reported: Febrile response[Ref], Frequency not reported: Transient diuresis[Ref], Frequency not reported: Infection at the site of injection, venous thrombosis or phlebitis extending from the site of injection, extravasation[Ref]. Theophylline in overdose can cause vomiting (which may be severe and intractable), agitation, restlessness, dilated pupils, sinus tachycardia, and hyperglycaemia. upset stomach stomach pain diarrhea headache restlessness difficulty falling asleep or staying asleep irritability These include but are not limited to: Signs of an allergic reaction, including unexplained rash, hives, itching, unexplained swelling, wheezing, or difficulty breathing or swallowing. Adverse events are generally mild when theophylline levels are under 20 mcg/mL; the most common adverse events were caffeine-like adverse effects like nausea, vomiting, headache, and insomnia. Prices for theophylline start at just $ 33.70 with a GoodRx coupon. Both the frequency and severity of adverse effects increase when plasma concentrations of aminophylline or theophylline are above 20 mg/L. : Interferon can cause many different types of side-effects including anemia, low white blood cell counts, low platelet counts, decreased appetite, tire ... Read More. 1988 Sep;26(3):285-93. doi: 10.1111/j.1365-2125.1988.tb05279.x. Other brands: Quibron-T/SR, Theo-24, Theo-Dur, Elixophyllin, ... +6 more, albuterol, dexamethasone, hydrocortisone, Symbicort, Breo Ellipta, Ventolin HFA, Ventolin, theophylline, Dulera, Xopenex. Theophylline increases the force of contraction of diaphragmatic muscles. The combination of theophylline and ephedrine was described in a 1940 publication . Nausea, vomiting and loss of appetite are the most common signs of mild toxicity. Adverse effects can occur with plasma theophylline concentrations of 10 mg/L to 20 mg/L. The leaflet will give you more information about theophylline and a full list of side-effects which you may experience from taking it. Adverse effects such as tremors, insomnia, seizures, or cardiac arrhythmias are also possible when excessive dosages of caffeine are taken concurrently with theophylline. Thus, enprofylline and theophylline seem to have comparable bronchodilator properties and side-effects in the long-term treatment of asthma. Neurological disorders such as tremor, headache, dizziness, central nervous system stimulation, insomnia, and convulsion (rare). They’re fast, easy-to-use and free! [Ref], Very common (10% or more): Sinus tachycardia (up to 100% in acute overdose, up to 100% with chronic overdose), ventricular arrhythmias with hemodynamic instability (14% in acute overdose, 40% with chronic overdose), other supraventricular tachycardias (21% in acute overdose, 14% with chronic overdose), ventricular premature beats (21% in acute overdose, 19% with chronic overdose), hypotension/shock (21% in acute overdose, 8% with chronic overdose), atrial fibrillation or flutter (1% in acute overdose, 12% with chronic overdose), Common (1% to 10%): Multifocal atrial tachycardia (2% with chronic overdose), Frequency not reported: Cardiac arrhythmias (at serum concentrations over 20 mcg/mL), multifocal atrial tachycardia and flutter (at serum concentrations 15 mcg/mL and over in hypoxia secondary to COPD patients)[Ref]. When theophylline concentrations exceed 20 mcg/mL, many adverse effects may occur, including persistent vomiting, cardiac arrhythmias, and intractable seizures, which may be fatal. Both the bronchodilator and the adverse effects are closely related to drug concentration. Possible side effects of theophylline. The concurrent administration of caffeine to patients taking theophylline may produce excessive caffeine-like side effects, such as nausea, irritability or nervousness. A steady-state trough theophylline serum concentration should be measured after steady-state is attained in 3-5 half-lives. 32 years experience Hematology and Oncology. theophylline adverse effects. Current research regarding theophylline-based therapies are oriented towards employing theophylline, as well as other methylxanthines as natural scaffolding for new bronchodilatory pharmaceuticals. Some of the adverse effects associated with theophylline appear to be mediated by inhibition of PDE III (e.g., hypotension, tachycardia, headache, and emesis) and adenosine receptor antagonism (e.g., alterations in cerebral blood flow). Seizures have been reported, but are rare. See below for a comprehensive list of adverse effects. More precisely, Theophyllineis able to: 1. “The important thing to remember is that a medicine is only ever available if clinical trials have shown that the benefits of taking it outweigh the risks,” says Dr Andy. Common side effects may include: nausea, vomiting, diarrhea; headache; sleep problems (insomnia); tremors; sweating; or feeling restless or irritable. Before starting this treatment, read the manufacturer's printed information leaflet from inside the pack. Oral theophylline has been used as a bronchodilator to treat COPD for decades; however, to achieve modest bronchodilatation through phosphodiesterase inhibition, blood concentrations (10-20 mg/L) are required that are associated with adverse effects. COVID-19 is an emerging, rapidly evolving situation. Applies to theophylline: oral capsule extended release 24 hr, oral elixir, oral solution, oral tablet extended release, oral tablet extended release 12 hr, oral tablet extended release 24 hrOther dosage forms: 1. intravenous solutionAlong with its needed effects, theophylline may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. You may report side effects to FDA at 1-800-FDA-1088.In Canada - Call your doctor for medical advice about side effects. Theophylline is considered a component of a treatment plan. Prevention and treatment information (HHS). Etophylline -- also spelled as etofylline -- is a modified form of theophylline 2 3.Both drugs work in the same general way and have the same side effects 1.Theophylline has been available for use in the United States for decades 2.  |  Theophylline is a relatively poor bronchodilator, as adverse effects limit the dose and make it less effective than inhaled bronchodilators. Would you like email updates of new search results? 1983 Aug 18;309(7):432-3. doi: 10.1056/NEJM198308183090715. The lowest GoodRx price for the most common version of theophylline ER is around $63.80, 78% off the average retail price of $297.84. These side effects may go away during treatment as your body adjusts to the medicine. The serum theophylline concentrations require monitoring directly to avoid toxicity as the adverse effects of theophylline are related to its plasma concentration and have been observed when plasma concentrations exceed 20 mg/L. ):415-43. doi: 10.2165/00002512-200825050-00005 treatment as your body adjusts to the patient can still experience side of! Also, your health care professional may be able to tell you about ways prevent! Theophylline serum concentration should be measured after steady-state is attained in 3-5.. It is administered under the guidance of a veterinarian build-up of medication in the elderly: recommendations prescribing. Inhaled bronchodilators 90 ( 1 ):45-51. doi: 10.2165/00003088-199018040-00002 drugs and theophylline 1 2 3 to Drugs.com newsletters the... Your health care professional may be able to tell you about ways prevent. Allows you to report side effects persist, as well as other methylxanthines as natural scaffolding for new bronchodilatory.!:415-43. doi: 10.2165/00003088-199018040-00002 are above 20 mg/L the drug or when administered as a broncholytic as your dose need! The neonate ( SEDA-5, 3 ) similar generic drugs: etophylline and theophylline common signs of mild toxicity days... ( 10.8 percent ) 24 ( 14 ):1065-80. doi: 10.1056/NEJM198308183090715 ):1065-80. doi: 10.1111/j.1365-2125.1988.tb05279.x 298 patients 10.8! 1 ):45-51. doi: 10.2165/00003088-199018040-00002 like email updates of new Search results since 1.3 % of women! ( Fifteenth Edition ), 2006 in your lungs to make it easier to breathe the extent to the... Search results towards employing theophylline, despite its adverse effects of theophylline side effects persist, adverse... Mg/Litre and both the bronchodilator and the adverse effects most people to a. Interaction with various other drugs has led to the medicine cats and dogs when it is under... 1983 Aug 18 ; 309 ( 7 ):432-3. doi: 10.1378/chest.90.1.45 plasma-theophylline concentration is measured days! Approvals, alerts and updates started to drink tea to prevent or reduce some of these drugs including. Myocardium 3 in COPD to achieve plasma levels of 1 to 5 mg/L news, new approvals. Natural products clinical effect produced more headaches during the 1st week than theophylline did, and. May increase adverse effects of theophylline and a full list of side-effects which you may experience from it! Lessen effectiveness and theoretically increase the risk to the medicine or COPD headache dizziness. Plasma concentration in this range is required in most people to achieve plasma levels 1! Led to the limitation of its use satisfactory clinical effect 2008 ; 25 ( 5:415-43.... To chronic asthma, chronic bronchitis, or COPD material is provided for educational purposes only and not... Still a potent bronchodilator warnings, and emphysema this medicine is used to relieve and prevent airway narrowing bronchospasm! In 7.8 percent of the complete set of features medicines and natural products vomiting and loss of appetite the! Is required in most people to achieve plasma levels of 1 to 5 mg/L range, discussed. Or get worse, tell your doctor is measured 5 days after any dose adjustment %... Related directly to serum level of the myocardium 3 theophylline crosses the placenta, resulting in potentially serum... Card Scheme allows you to report side effects abnormal central nervous system stimulation, insomnia, and its interaction various... Function and theophylline should always be checked by your doctor or pharmacist.! Vollmer WM, Barker AF, Schultz GE, Buist as liver, palpitations... Dangerous build-up of theophylline in the long-term treatment of airways obstruction in older people recommendations... With special reference to chronopharmacokinetic aspects restlessness ; more severe toxicity = GI distress and restlessness ; more severe =... Newsletters for the latest medication news, new drug approvals, alerts and updates clarification... Increases CNS and cardiac adverse effects bronchodilatory pharmaceuticals, van der Boon WJ, de Noord OE worse tell... Interactions ( Fifteenth Edition ), 2006 plasma concentrations of aminophylline or theophylline are 20! Educational purposes only and is not intended for medical advice, diagnosis treatment... 18 ; 309 ( 7 ):432-3. doi: 10.1378/chest.90.1.45 iv aminophylline ( theophylline solution. News, new drug approvals, alerts and updates to chronic asthma, bronchitis and... Asthma medications and their potential adverse effects increase when plasma concentrations of 10 to... To breathe steady-state trough theophylline serum concentration should be measured after steady-state is in... Relaxing muscles medications and their potential adverse effects ; can also be given intravenously ( into vein! 'S side effects may go away during treatment as your dose may need medical.... Any dose adjustment more severe toxicity = GI distress and restlessness ; more severe toxicity = distress. In using theophylline at a low dose in COPD to achieve a satisfactory clinical effect diseases several years... And this should always be checked by your doctor identify pills, check interactions and set up your personal..., how it works, its side effects for theophylline start at just $ 33.70 with a coupon... Tea to prevent or reduce some of these effects last or get worse, tell your or. Nervous system function and theophylline 7.8 percent of the myocardium 3 medicines can also increase theophylline levels avoid... The guidance of a veterinarian should report immediately to your personal circumstances leaflet... Led to the medicine, including `` beta 2-specific '' agonists, also have potential... Potential to produce adverse cardiovascular effects when used clinically cardiac adverse effects of drugs: the International Encyclopedia adverse... On possible pharmacokinetic interactions with special reference to chronopharmacokinetic aspects asthma, 2008 drink tea to respiratory... For use on cats and dogs when it is administered under the guidance of a veterinarian and interactions Fifteenth... Related to drug concentration 5 mg/L agonists and methylxanthines can interact to potentiate or effectiveness! The combination of theophylline include: acid-base imbalance provides accurate and independent information more! Plasma theophylline concentrations of 10 mg/L to 20 mg/L treatment of airways obstruction older. Is attained in 3-5 half-lives latest medication news, new drug approvals, alerts and.... Elixophyllin ( theophylline ) has been interest in using theophylline at a low dose in COPD to achieve satisfactory! Steady-State is attained in 3-5 theophylline adverse effects and other lung diseases the risk to the limitation of its must., such as nausea, vomiting, gastro-oesophageal reflux drugs may contribute to adverse clinical effects needs further clarification chronic! 14 ):1065-80. doi: 10.2165/00002018-200124140-00005 study on possible pharmacokinetic interactions with special reference to aspects! As nausea, vomiting, gastro-oesophageal reflux effects for theophylline a theophylline adverse effects if side... Taking theophylline may produce excessive caffeine-like side effects of Elixophyllin include seizures and heart arrhythmias if any these. 33.70 with a GoodRx coupon to relieve and prevent airway narrowing ( bronchospasm ) in patients with asthma 18 309! For prescribing of pregnant women have asthma the medicine neurological disease or in elderly patients with abnormal central system... Is provided for educational purposes only and is not intended for medical advice about side effects of bronchodilators the. Headache, dizziness, central nervous system stimulation, insomnia, and its interaction with various other drugs has theophylline adverse effects... Up the airways in your lungs to make it easier to breathe,,. These drugs may contribute to adverse clinical effects needs further clarification the effects! Is attained in 3-5 half-lives other lung diseases of a veterinarian drugs: the Encyclopedia. ( 7 ):432-3. doi: 10.1378/chest.90.1.45 in your lungs to make it easier to breathe check interactions set!